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KMID : 0377819940140050553
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Diagnosis and Treatment
1994 Volume.14 No. 5 p.553 ~ p.555
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ORGANIC AFFECTIVE DISORDER CAUSED BY INTERFERON-α
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Abstract
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Interferon-a is the only approved and effective treatment for hepatitis C. Psychiatric side effects are common and have frequently required a decrease in dose or discontinuation of therapy.1), 2)
The psychiatric side effects fell into three categories : an organic personality syndrome characterized by irritability and short temper ; an organic affective syndrome marked by extreme emotional liability, depression, and tearfulness ; and a delirium marked by clouding of consciousness, agitation, paranoia, and suicidal potential.
Failure to recognize these side effects quickly and to treat them with supportive therapy and modification of the dose of interferon alfa could result in limitation of therapy and serious personal and interpersonal consequences.
We here report a case of interferon-ainduced organic affective disorder in a 42-yrold woman with hepatitis and review about the psychiatric complications of long-term Interferon alfa pherapy.
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KEYWORD
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